Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

V(D)J rearrangement in Nijmegen breakage syndrome.

Molecular immunology - 1 Dec 2000

Yeo T C, Xia D, Hassouneh S, Yang X O, Sabath D E, Sperling K, Gatti R A, Concannon P, Willerford D M

Abstract excerpt

Repair of DNA double-strand breaks is essential for maintenance of genomic stability, and is specifically required for rearrangement of immunoglobulin (Ig) and T cell receptor (TCR) loci during development of the immune system. Abnormalities in these repair processes also contribute to oncogenic chromosomal rearrangements that underlie many lymphoid malignancies. Nijmegen breakage syndrome (NBS) is a rare...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abnormalities, Multiple
Share to Chromosome Breakage
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement, B-Lymphocyte

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin kappa-Chains

Share to MRE11 Homologue Protein

Share to Syndrome

Source

Identifiers

PMID: 11451418
DOI: 10.1016/s0161-5890(01)00026-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

V(D)J rearrangement in Nijmegen breakage syndrome.PMID 11451418Read ↗

Nijmegen breakage syndrome (NBS)Semantic proximity Read ↗

Dual functions of Nbs1 in the repair of DNA breaks and proliferation ensure proper V(D)J recombination and T-cell development.Semantic proximity Read ↗

Loss of juxtaposition of RAG-induced immunoglobulin DNA ends is implicated in the precursor B-cell differentiation defect in NBS patientsSemantic proximity Read ↗

Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.Semantic proximity Read ↗

A murine model of Nijmegen breakage syndrome.Semantic proximity Read ↗

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage SyndromeSemantic proximity Read ↗

Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks.Semantic proximity Read ↗

Nuclear export of NBN is required for normal cellular responses to radiation.Semantic proximity Read ↗

Immortalization and characterization of Nijmegen Breakage syndrome fibroblasts.Semantic proximity Read ↗

657del5 mutation in the gene for Nijmegen breakage syndrome (NBS1) in a cohort of Russian children with lymphoid tissue malignancies and controls.Semantic proximity Read ↗

Nijmegen Breakage Syndrome (NBS) is a Telomeropathy: Analysis of Telomere Length in NBS Homo- and Heterozygotes and Humanized Nbs MiceSemantic proximity Read ↗

Nonhomologous end joining and V(D)J recombination require an additional factorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.