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Article

Tetracaine, a local anesthetic, preferentially induces translational inhibition with processing body formation rather than phosphorylation of eIF2α in yeast.

Current genetics - 1 Feb 2015

Araki Tomoyuki, Toh-e Akio, Kikuchi Yoshiko, Watanabe Chihiro K, Hachiya Takushi, Noguchi Ko, Terashima Ichiro, Uesono Yukifumi

Abstract excerpt

It is unclear whether local anesthetics, such as tetracaine, and antipsychotics, such as phenothiazines, act on lipids or proteins. In Saccharomyces cerevisiae, these drugs inhibit growth, translation initiation, and actin polarization, and induce cell lysis at high concentrations. These activiti...

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PMID: 25119673
DOI: 10.1007/s00294-014-0443-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25119673-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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