Article
Defects in the secretory pathway and high Ca2+ induce multiple P-bodies.
Molecular biology of the cell - 1 Aug 2010
Kilchert Cornelia, Weidner Julie, Prescianotto-Baschong Cristina, Spang Anne
Abstract excerpt
mRNA is sequestered and turned over in cytoplasmic processing bodies (PBs), which are induced by various cellular stresses. Unexpectedly, in Saccharomyces cerevisiae, mutants of the small GTPase Arf1 and various secretory pathway mutants induced a significant increase in PB number, compared with PB induction by starvation or oxidative stress. Exposure of wild-type cells to osmotic stress or high extracellular...
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