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Article

Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors.

Trends in neurosciences - 1 Jul 2003

Kirik Deniz, Björklund Anders

Abstract excerpt

Defective handling of proteins is a central feature of major neurodegenerative diseases. The discovery that neuronal dysfunction or degeneration can be caused by mutations in single cellular proteins has given new opportunities to model the underlying disease processes by genetic modification of...

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PMID: 12850435
DOI: 10.1016/S0166-2236(03)00164-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12850435-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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