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Autologous haematopoietic stem cell transplantation reduces abnormalities in the expression of immune genes in multiple sclerosis

14 Aug 2014

Abstract excerpt

Autologous haematopoietic stem-cell transplantation (AHSCT) has been experimented as a treatment in patients affected by severe forms of multiple sclerosis (MS) who failed to respond to standard immunotherapy. The rationale of AHSCT is to 'reboot' the immune system and reconstitute a new adaptive immunity. The aim of our study was to identify, through a robust and unbiased transcriptomic analysis, any changes of...

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PMID: 25116724
DOI: 10.1042/cs20140095

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