Article
No proinflammatory signature in CD34+ hematopoietic progenitor cells in multiple sclerosis patients.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Aug 2012
Lutterotti A, Jelcić I, Schulze C, Schippling S, Breiden P, Mazzanti B, Reinhardt S, DiGioia M, Repice A, Massacesi L, Sputtek A, Salinas-Riester G, Kroeger N, Sospedra M, Saccardi R, Zander A, Martin R
Abstract excerpt
Autologous hematopoietic stem cell transplantation (aHSCT) has been used as a therapeutic approach in multiple sclerosis (MS). However, it is still unclear if the immune system that emerges from autologous CD34+ hematopoietic progenitor cells (HPC) of MS patients is pre-conditioned to re-develop the proinflammatory phenotype. The objective of this article is to compare the whole genome gene and microRNA...
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