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Gene expression profiling in multiple sclerosis: a disease of the central nervous system, but with relapses triggered in the periphery?

Neurobiology of disease - 1 Mar 2010

Brynedal Boel, Khademi Mohsen, Wallström Erik, Hillert Jan, Olsson Tomas, Duvefelt Kristina

Abstract excerpt

The aetiology of multiple sclerosis (MS), an autoimmune demyelinating disease of the central nervous system (CNS), includes both genetic and environmental factors, but the pathogenesis is still incompletely known. We performed gene expression profiling on paired cerebrospinal fluid (CSF) and peripheral blood mononuclear cells (PBMCs) samples from 26 MS patients without immunomodulatory treatment, sampled in...

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Cerebrospinal Fluid
Gene Regulatory Networks
Leukocytes, Mononuclear
Multiple Sclerosis
Oligonucleotide Array Sequence Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Predictive Value of Tests

Sensitivity and Specificity

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PMID: 19944761
DOI: 10.1016/j.nbd.2009.11.014

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