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Article

Homocysteine and nitrite levels are modulated by MTHFR 677C>T polymorphism in obese women treated with simvastatin.

Clinical and experimental pharmacology & physiology - 1 Oct 2014

Villela Maria P, Andrade Vanessa L, Eccard Bryelle, Jordão Alceu A, Sertório Jonas T, Tanus-Santos Jose E, Silva Ieda F O, Silveira Josianne N, Sandrim Valéria C

Abstract excerpt

Higher homocysteine (Hcy) levels are associated with cardiovascular risk. The aim of the present study was to evaluate the effect of simvastatin treatment on circulating Hcy levels in obese women without hypertension, diabetes or dyslipidaemia; and to determine whether the 677C>T polymorphism located in methylenetetrahydrofolate reductase (NAD(P)H) (MTHFR) gene modulates the effects of this treatment on Hcy and...

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Source

Identifiers

PMID: 25115547
DOI: 10.1111/1440-1681.12284

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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