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Article

Characterization of nodal/TGF-lefty signaling pathway gene variants for possible roles in congenital heart diseases.

PloS one - 1 Jan 2014

Deng Xia, Zhou Jing, Li Fei-Feng, Yan Peng, Zhao Er-Ying, Hao Ling, Yu Kai-Jiang, Liu Shu-Lin

Abstract excerpt

BACKGROUND: Nodal/TGF-Lefty signaling pathway has important effects at early stages of differentiation of human embryonic stem cells in directing them to differentiate into different embryonic lineages. LEFTY, one of transforming growth factors in the Nodal/TGF-Lefty signaling pathway, plays an important role in the development of heart. The aim of this work was to find evidence on whether Lefty variations are...

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Identifiers

PMID: 25111179
DOI: 10.1371/journal.pone.0104535
PMCID: PMC4128709

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