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Article

PI3K/Akt-mediated regulation of p53 in cancer

1 Aug 2014

Abstract excerpt

Mutations activating the PI3K (phosphoinositide 3-kinase)/Akt signalling pathway and inactivating the TP53 tumour-suppressor gene are common mechanisms that cancer cells require to proliferate and escape pre-programmed cell death. In a well-described mechanism, Akt mediates negative control of p53 levels through enhancing MDM2 (murine double minute 2)-mediated targeting of p53 for degradation. Accumulating...

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PMID: 25109960
DOI: 10.1042/bst20140070

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