A research study of the association between maternal microchimerism and systemic lupus erythematosus in adults: a comparison between patients and healthy controls based on single-nucleotide polymorphism using quantitative real-time PCR.

doi:10.1371/journal.pone.0074534

Article

A research study of the association between maternal microchimerism and systemic lupus erythematosus in adults: a comparison between patients and healthy controls based on single-nucleotide polymorphism using quantitative real-time PCR.

PloS one - 1 Jan 2013

Kanold Anna Maria Jonsson, Svenungsson Elisabet, Gunnarsson Iva, Götherström Cecilia, Padyukov Leonid, Papadogiannakis Nikos, Uzunel Mehmet, Westgren Magnus

Abstract excerpt

BACKGROUND: Naturally acquired microchimerism may arise in the mother and her child during pregnancy when bidirectional trafficking of cells occurs through the placental barrier. The occurrence of maternal microchimerism (maternal cells in the offspring) has been associated with several autoimmune diseases, especially in children. Systemic Lupus erythematosus (SLE) is an autoimmune disorder with a resemblance to...

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A research study of the association between maternal microchimerism and systemic lupus erythematosus in adults: a comparison between patients and healthy controls based on single-nucleotide polymorphism using quantitative real-time PCR.

Abstract excerpt

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