Article
Perinatal lead (Pb) exposure results in sex-specific effects on food intake, fat, weight, and insulin response across the murine life-course.
PloS one - 1 Jan 2014
Faulk Christopher, Barks Amanda, Sánchez Brisa N, Zhang Zhenzhen, Anderson Olivia S, Peterson Karen E, Dolinoy Dana C
Abstract excerpt
Developmental lead (Pb) exposure has been associated with lower body weight in human infants and late onset obesity in mice. We determined the association of perinatal Pb exposure in mice with changes in obesity-related phenotypes into adulthood. Mice underwent exposure via maternal drinking water supplemented with 0 (control), 2.1 (low), 16 (medium), or 32 (high) ppm Pb-acetate two weeks prior to mating through...
Topics
- Age Factors
- Animals
- Area Under Curve
- Blood Glucose
- Body Composition
- Body Weight
- Dose-Response Relationship, Drug
- Eating
- Energy Metabolism
- Female
- Glucose Tolerance Test
- Lead
- Linear Models