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Article

The microRNA-15 family inhibits the TGFβ-pathway in the heart

7 Aug 2014

Abstract excerpt

AIMS: The overloaded heart remodels by cardiomyocyte hypertrophy and interstitial fibrosis, which contributes to the development of heart failure. Signalling via the TGFβ-pathway is crucial for this remodelling. Here we tested the hypothesis that microRNAs in the overloaded heart regulate this remodelling process via inhibition of the TGFβ-pathway. METHODS AND RESULTS: We show that the miRNA-15 family, which we...

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Share to Cardiac Fibrosis and Remodeling
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PMID: 25103110
DOI: 10.1093/cvr/cvu184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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