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Article

Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function

9 Oct 2012

Abstract excerpt

MicroRNAs are dysregulated in a setting of heart disease and have emerged as promising therapeutic targets. MicroRNA-34 family members (miR-34a, -34b, and -34c) are up-regulated in the heart in response to stress. In this study, we assessed whether inhibition of the miR-34 family using an s.c.-delivered seed-targeting 8-mer locked nucleic acid (LNA)-modified antimiR (LNA-antimiR-34) can provide therapeutic...

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PMID: 23047694
DOI: 10.1073/pnas.1206432109

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