Mutational analysis demonstrates that specific electrostatic interactions can play a key role in the denatured state ensemble of proteins.

Abstract excerpt

The nature of the denatured state ensemble has been controversial for decades owing, in large part, to the difficulty in characterizing the structure and energetics of denatured state interactions. There is increasing evidence for relatively non-specific hydrophobic clustering in the denatured states of some proteins but other types of interactions are much less well characterized. Here, we report the...

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