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Article

The significance of the F variant of alpha-1-antitrypsin and unique case report of a PiFF homozygote.

BMC pulmonary medicine - 7 Aug 2014

Sinden Nicola Jane, Koura Firas, Stockley Robert Andrew

Abstract excerpt

BACKGROUND: Inheritance of the F variant of alpha-1-antitrypsin is associated with normal circulating protein levels, but it is believed to be dysfunctional in its ability to inhibit neutrophil elastase and therefore has been implicated as a susceptibility factor for the development of emphysema. In this study, its functional characteristics were determined following the identification of a unique patient with...

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Source

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Identifiers

PMID: 25098359
DOI: 10.1186/1471-2466-14-132
PMCID: PMC4131482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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