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Article

Kinetic characterisation of alpha-1-antitrypsin F as an inhibitor of human neutrophil elastase.

Pathology - 1 Aug 1996

Cook L, Burdon J G, Brenton S, Knight K R, Janus E D

Abstract excerpt

Patients homozygous for the Z allele of alpha-1-antitrypsin (alpha 1AT) have very low serum levels and are predisposed to emphysema. There have also been reports of emphysema being associated with the heterozygous phenotype FZ. To investigate whether F alpha 1AT was dysfunctional, the inhibitory activity of F alpha 1AT against human neutrophil elastase (HNE) was compared with that of common alpha 1AT phenotypes....

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Identifiers

PMID: 8912354
DOI: 10.1080/00313029600169074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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