Kinetic characterisation of alpha-1-antitrypsin F as an inhibitor of human neutrophil elastase.

doi:10.1080/00313029600169074

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Article

Kinetic characterisation of alpha-1-antitrypsin F as an inhibitor of human neutrophil elastase.

Pathology - 1 Aug 1996

Cook L, Burdon J G, Brenton S, Knight K R, Janus E D

Abstract excerpt

Patients homozygous for the Z allele of alpha-1-antitrypsin (alpha 1AT) have very low serum levels and are predisposed to emphysema. There have also been reports of emphysema being associated with the heterozygous phenotype FZ. To investigate whether F alpha 1AT was dysfunctional, the inhibitory activity of F alpha 1AT against human neutrophil elastase (HNE) was compared with that of common alpha 1AT phenotypes....

Topics

Adult
Alleles
DNA
Emphysema
Female
Humans
Isoelectric Focusing
Leukocyte Elastase
Male
Middle Aged
Mutation
Phenotype
alpha 1-Antitrypsin

Source

Open in PubMed

Identifiers

PMID: 8912354
DOI: 10.1080/00313029600169074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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