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Gracilins: Spongionella-derived promising compounds for Alzheimer disease.

Neuropharmacology - 1 Jun 2015

Leirós Marta, Alonso Eva, Rateb Mostafa E, Houssen Wael E, Ebel Rainer, Jaspars Marcel, Alfonso Amparo, Botana Luis M

Abstract excerpt

Alzheimer disease (AD) is a neurodegenerative pathology that is strongly linked with oxidative stress and mitochondrial dysfunction. The unclear origin of AD lead researchers to study several drug targets and it has been proposed that a multi-target drug would be a more promising candidate. Gracilins are sponge-derived diterpenoid compounds that have been described to act as antioxidants through mitochondrial...

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PMID: 25724081
DOI: 10.1016/j.neuropharm.2015.02.015

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BACE1
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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