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Article

Epigenetic inactivation of the novel candidate tumor suppressor gene ITIH5 in colon cancer predicts unfavorable overall survival in the CpG island methylator phenotype.

Epigenetics - 1 Sept 2014

Kloten Vera, Rose Michael, Kaspar Sophie, von Stillfried Saskia, Knüchel Ruth, Dahl Edgar

Abstract excerpt

Inter-α-trypsin inhibitor heavy chain 5 (ITIH5) is supposed to be involved in extracellular matrix stability and thus may play a key role in the inhibition of tumor progression. The current study is the first to analyze in depth ITIH5 expression as well as its potential clinical and functional impact in colon cancer. Based on 30 tumor and 30 adjacent normal tissues we examined ITIH5 mRNA expression and promoter...

Read the complete abstract on PubMed

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Share to Caco-2 Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, Tumor Suppressor

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Share to Proteinase Inhibitory Proteins, Secretory

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Source

Open in PubMed Open full text

Identifiers

PMID: 25093535
DOI: 10.4161/epi.32089
PMCID: PMC4169021

Genes

ITIH5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Epigenetic inactivation of the novel candidate tumor suppressor gene ITIH5 in colon cancer predicts unfavorable overall survival in the CpG island methylator phenotype.PMID 25093535Read ↗

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Low expression of ITIH5 in adenocarcinoma of the lung is associated with unfavorable patients' outcomeSemantic proximity Read ↗

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[Novel prognostic marker in invasive breast cancer. ITIH5 expression is abrogated by aberrant promoter methylation].Semantic proximity Read ↗

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Predicting clinical outcome of 5-fluorouracil-based chemotherapy for colon cancer patients: is the CpG island methylator phenotype the 5-fluorouracil-responsive subgroup?Semantic proximity Read ↗

Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: A systematic expression analysisSemantic proximity Read ↗

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