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Article

[Novel prognostic marker in invasive breast cancer. ITIH5 expression is abrogated by aberrant promoter methylation].

Der Pathologe - 1 Nov 2008

Veeck J, Breuer E, Rose M, Chorovicer M, Naami A, Bektas N, Alkaya S, von Serényi S, Horn F, Hartmann A, Knüchel R, Dahl E

Abstract excerpt

We have recently characterized ITIH5 as a new extracellular matrix protein that exhibits clear expression loss in a variety of human tumour entities, including breast cancer. The aim of the present study was to decipher the molecular cause of ITIH5 expression loss in breast cancer and to learn more about the possible role of this molecule in cancer diseases. ITIH5 protein expression was found to be strongly...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18810445
DOI: 10.1007/s00292-008-1044-9

Genes

ITIH5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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[Novel prognostic marker in invasive breast cancer. ITIH5 expression is abrogated by aberrant promoter methylation].PMID 18810445Read ↗

The extracellular matrix protein ITIH5 is a novel prognostic marker in invasive node-negative breast cancer and its aberrant expression is caused by promoter hypermethylationSemantic proximity Read ↗

ITIH5 induces a shift in TGF‐β superfamily signaling involving Endoglin and reduces risk for breast cancer metastasis and tumor deathSemantic proximity Read ↗

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Gene expression analysis combined with functional genomics approach identifies ITIH5 as tumor suppressor gene in cervical carcinogenesisSemantic proximity Read ↗

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Low expression of ITIH5 in adenocarcinoma of the lung is associated with unfavorable patients' outcomeSemantic proximity Read ↗

Epigenetic inactivation of the novel candidate tumor suppressor gene ITIH5 in colon cancer predicts unfavorable overall survival in the CpG island methylator phenotype.Semantic proximity Read ↗

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The expression of BIRC5 is correlated with loss of specific chromosomal regions in breast carcinomasSemantic proximity Read ↗

Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: A systematic expression analysisSemantic proximity Read ↗

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