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Article

The influence of pathological mutations and proline substitutions in TDP-43 glycine-rich peptides on its amyloid properties and cellular toxicity.

PloS one - 1 Jan 2014

Sun Chia-Sui, Wang Cindy Yu-Hsiang, Chen Bryan Po-Wen, He Ruei-Yu, Liu Gerard Chun-Hao, Wang Chih-Hsien, Chen Wenlung, Chern Yijuang, Huang Joseph Jen-Tse

Abstract excerpt

TAR DNA-binding protein (TDP-43) was identified as the major ubiquitinated component deposited in the inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) in 2006. Later on, numerous ALS-related mutations were found in either the glycine or glutamine/asparagine-rich region on the TDP-43 C-terminus, which hinted on the importance...

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Identifiers

PMID: 25090004
DOI: 10.1371/journal.pone.0103644
PMCID: PMC4121164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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