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Article

Importance of the Q/N-rich segment for protein stability of endogenous mouse TDP-43.

Scientific reports - 2 Sept 2022

Sato Toshiya, Oda Kanako, Sakai Seiko, Kato Rika, Yamamori Saori, Itakura Makoto, Kodera Yoshio, Nishizawa Masatoyo, Sasaoka Toshikuni, Onodera Osamu, Yokoyama Minesuke

Abstract excerpt

TAR DNA-binding protein 43 kDa (TDP-43), a nuclear protein, plays an important role in the molecular pathogenesis of amyotrophic lateral sclerosis (ALS). The long-disordered C-terminal region (CTR) of TDP-43 is known to be aggregation-prone and a hotspot for ALS mutations, so elucidation of the physiological function of CTR will provide insights into the pathogenesis of ALS. The CTR has two Gly, aromatic, and...

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Identifiers

PMID: 36056157
DOI: 10.1038/s41598-022-19153-0
PMCID: PMC9440050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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