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Article

Rapid, accurate detection of TMPRSS6 gene causative mutations with a high-resolution melting assay.

Blood cells, molecules & diseases - 15 Oct 2011

Wu He-Ming, Li Liang, Yuan Xiao-Wen, Zhou Yu-Qiu, Xiao Qi-Zhi, Liu Wei-Yu, Zhou Wan-Jun, Xu Xiang-Min

Abstract excerpt

Mutations of the TMPRSS6 gene are considered the major genetic factors for iron-refractory iron deficiency anemia (IRIDA). Artificial clone libraries containing 17 known mutations of the TMPRSS6 gene were used to develop a high-resolution melting (HRM) assay for the detection of 17 TMPRSS6 gene mutations. The melting temperatures and melting curves were able to distinguish the different genotypes of the 17...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21783390
DOI: 10.1016/j.bcmd.2011.06.004

Genes

TMPRSS6

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