Article
Mutual amplification of corticosteroids and angiotensin systems in human vascular smooth muscle cells and carotid atheroma.
Journal of molecular medicine (Berlin, Germany) - 1 Nov 2014
Ayari Hanène, Legedz Liliana, Cerutti Catherine, Lantelme Pierre, Feugier Patrick, Gustin Marie-Paule, Lohez Olivier, Nehme Ali, Li Jacques Yuan, Gharbi-Chihi Jouda, Bricca Giampiero
Abstract excerpt
UNLABELLED: The involvement of the renin-angiotensin-aldosterone system (RAAS) and cortisol in increased cardiovascular risk is well known. If numerous relationships between RAAS and corticosteroids have been described, their interactions within the arterial wall, especially during the transdifferentiation of vascular smooth muscle cells (VSMCs) and the atheroma formation, are not established. Here, we clarified...
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