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Steroidogenic Enzyme Gene Expression in the Human Heart<sup>1</sup>

1 Jul 2000

Abstract excerpt

Corticosteroids have specific effects on cardiac structure and function mediated by mineralocorticoid (MR) and glucocorticoid (GR) receptors. Aldosterone and corticosterone are synthesized in the rat heart. To see whether they might also be synthesized in the human cardiovascular system, we examined the expression of genes for steroidogenic enzymes as well as genes for GR, MR, and 11-hydroxysteroid dehydrogenase...

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PMID: 10902803
DOI: 10.1210/jcem.85.7.6663

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