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Article

Single nucleotide polymorphism typing with a surface plasmon resonance-based sensor using hybridization enhancement blockers.

Applied biochemistry and biotechnology - 1 Sept 2014

Okumura Shiro, Kuroda Rieko, Inouye Kuniyo

Abstract excerpt

We constructed a simple method for discrimination of single nucleotide polymorphism (SNP) with a surface plasmon resonance (SPR)-based sensor by determining the binding volume (BV) between a target SNP allele and a probe complementary to the target. In the method, a novel additive termed "blocker," which is a short single-stranded DNA complementary to the target, was used. The blocker enhanced the BV of the...

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PMID: 25082764
DOI: 10.1007/s12010-014-1072-2

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SPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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