Article
Shared genetic factors influence amygdala volumes and risk for alcoholism.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2015
Dager Alecia D, McKay D Reese, Kent Jack W, Curran Joanne E, Knowles Emma, Sprooten Emma, Göring Harald H H, Dyer Thomas D, Pearlson Godfrey D, Olvera Rene L, Fox Peter T, Lovallo William R, Duggirala Ravi, Almasy Laura, Blangero John, Glahn David C
Abstract excerpt
Alcohol abuse and dependence (alcohol use disorders, AUDs) are associated with brain shrinkage. Subcortical structures including the amygdala, hippocampus, ventral striatum, dorsal striatum, and thalamus subserve reward functioning and may be particularly vulnerable to alcohol-related damage. These structures may also show pre-existing deficits impacting the development and maintenance of AUD. It remains unclear...
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