Article
Heritability of subcortical brain measures: a perspective for future genome-wide association studies.
NeuroImage - 1 Dec 2013
den Braber Anouk, Bohlken Marc M, Brouwer Rachel M, van 't Ent Dennis, Kanai Ryota, Kahn René S, de Geus Eco J C, Hulshoff Pol Hilleke E, Boomsma Dorret I
Abstract excerpt
Several large imaging-genetics consortia aim to identify genetic variants influencing subcortical brain volumes. We investigated the extent to which genetic variation accounts for the variation in subcortical volumes, including thalamus, amygdala, putamen, caudate nucleus, globus pallidus and nucleus accumbens and obtained the stability of these brain volumes over a five-year period. The heritability estimates...
Topics
- Aging
- Brain
- Endophenotypes
- Female
- Genetic Variation
- Genome-Wide Association Study
- Humans
- Longitudinal Studies
- Male
- Organ Size
- Reproducibility of Results