Article
Mitochondrial genomic variation associated with higher mitochondrial copy number: the Cache County Study on Memory Health and Aging.
BMC bioinformatics - 1 Jan 2014
Ridge Perry G, Maxwell Taylor J, Foutz Spencer J, Bailey Matthew H, Corcoran Christopher D, Tschanz JoAnn T, Norton Maria C, Munger Ronald G, O'Brien Elizabeth, Kerber Richard A, Cawthon Richard M, Kauwe John S K
Abstract excerpt
BACKGROUND: The mitochondria are essential organelles and are the location of cellular respiration, which is responsible for the majority of ATP production. Each cell contains multiple mitochondria, and each mitochondrion contains multiple copies of its own circular genome. The ratio of mitochondrial genomes to nuclear genomes is referred to as mitochondrial copy number. Decreases in mitochondrial copy number are...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.