Article

An immunogenic model of KRAS-mutant lung cancer for study of targeted therapy and immunotherapy combinations

2020-12-22

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in oncogenes such as KRAS and EGFR cause a high proportion of lung cancers. Drugs targeting these proteins cause tumour regression but ultimately fail to cure these cancers, leading to intense interest in how best to combine them with other treatments, such as immunotherapies. However, preclinical systems for studying the interaction of lung tumours with the host immune system are inad...

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Literature Corpus work: 93a053f3-310f-51b7-b29e-ce85499635df
DOI: 10.1101/2020.12.22.423126

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