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Article

Activation of the dormant secondary metabolite production by introducing gentamicin-resistance in a marine-derived Penicillium purpurogenum G59.

Marine drugs - 1 Mar 2012

Chai Yun-Jing, Cui Cheng-Bin, Li Chang-Wei, Wu Chang-Jing, Tian Cong-Kui, Hua Wei

Abstract excerpt

A new approach to activate silent gene clusters for dormant secondary metabolite production has been developed by introducing gentamicin-resistance to an originally inactive, marine-derived fungal strain Penicillium purpurogenum G59. Upon treatment of the G59 spores with a high concentration of gentamicin in aqueous DMSO, a total of 181 mutants were obtained by single colony isolation. In contrast to the strain...

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Identifiers

PMID: 22611354
DOI: 10.3390/md10030559
PMCID: PMC3347015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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