Article
Design, synthesis, and antiviral evaluation of novel hydrazone-substituted thiophene[3,2-d]pyrimidine derivatives as potent human immunodeficiency virus-1 inhibitors.
Chemical biology & drug design - 1 Dec 2018
Wang Zhao, Kang Dongwei, Chen Meng, Wu Gaochan, Feng Da, Zhao Tong, Zhou Zhongxia, Huo Zhipeng, Jing Lanlan, Zuo Xiaofang, Daelemans Dirk, De Clercq Erik, Pannecouque Christophe, Zhan Peng, Liu Xinyong
Abstract excerpt
In the previous studies of our laboratory, the thiophene[3,2-d]pyrimidine was identified as a promising scaffold for seeking highly potent HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). In this study, we designed, synthesized, and biologically evaluated a series of thiophene[3,2-d]pyrimidine derivatives with changed linker between the thiophenepyrimidine core and the right wing. Some of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.