Article
Evaluation of eight live attenuated vaccine candidates for protection against challenge with virulent Mycobacterium avium subspecies paratuberculosis in mice.
Frontiers in cellular and infection microbiology - 1 Jan 2014
Bannantine John P, Everman Jamie L, Rose Sasha J, Babrak Lmar, Katani Robab, Barletta Raúl G, Talaat Adel M, Gröhn Yrjö T, Chang Yung-Fu, Kapur Vivek, Bermudez Luiz E
Abstract excerpt
Johne's disease is caused by Mycobacterium avium subsp. paratuberculosis (MAP), which results in serious economic losses worldwide in farmed livestock such as cattle, sheep, and goats. To control this disease, an effective vaccine with minimal adverse effects is needed. In order to identify a live vaccine for Johne's disease, we evaluated eight attenuated mutant strains of MAP using a C57BL/6 mouse model. The...
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