Molecular basis and zygosity determination of D variants including identification of four novel alleles in Chinese individuals.

doi:10.1111/trf.12797

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Article

Molecular basis and zygosity determination of D variants including identification of four novel alleles in Chinese individuals.

Transfusion - 1 Jan 2015

He Ji, Ying Yanling, Hong Xiaozhen, Xu Xianguo, Zhu Faming, Lv Hangjun

Abstract excerpt

BACKGROUND: The frequency and molecular basis of the D variants have been reported in the Caucasian and African populations, but relatively little information was known in the Chinese population. Here, a study was investigated in Chinese persons with weak or discrepant D serologic typing. STUDY DESIGN AND METHODS: D variant was typed with a serologic method. The full coding regions of RHD of these variants were...

Topics

Alleles
Asian People
Blood Grouping and Crossmatching
China
Ethnicity
Gene Dosage
Genetic Variation
Genotype
Humans
Multiplex Polymerase Chain Reaction
Mutation
Polymerase Chain Reaction
Rh-Hr Blood-Group System
Sequence Analysis, DNA

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PMID: 25070883
DOI: 10.1111/trf.12797

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