Variants of ERCC5 and the outcome of platinum-based regimens in non-small cell lung cancer: a prospective cohort study.

doi:10.1007/s12032-022-01741-9

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Article

Variants of ERCC5 and the outcome of platinum-based regimens in non-small cell lung cancer: a prospective cohort study.

Medical oncology (Northwood, London, England) - 19 Jul 2022

Abdalkhalek Esraa S, Wakeel Lamia M El, Nagy Ahmed A, Sabri Nagwa A

Abstract excerpt

Excision repair complementary complex 5 (ERCC5) is an important component in the repair pathway of platinum-induced damage. The current study evaluated the effect of ERCC5 variants (rs751402 and rs1047768) on the clinical outcome of platinum-based regimens in non-small cell lung cancer (NSCLC) patients. A prospective, cohort study was conducted on 57 newly diagnosed NSCLC Egyptian patients. Patients received...

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Identifiers

PMID: 35852645
DOI: 10.1007/s12032-022-01741-9
PMCID: PMC9296400

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