Article
Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents.
Journal of medical genetics - 1 Feb 2007
Goldstein Alisa M, Chan May, Harland Mark, Hayward Nicholas K, Demenais Florence, Bishop D Timothy, Azizi Esther, Bergman Wilma, Bianchi-Scarra Giovanna, Bruno William, Calista Donato, Albright Lisa A Cannon, Chaudru Valerie, Chompret Agnes, Cuellar Francisco, Elder David E, Ghiorzo Paola, Gillanders Elizabeth M, Gruis Nelleke A, Hansson Johan, Hogg David, Holland Elizabeth A, Kanetsky Peter A, Kefford Richard F, Landi Maria Teresa, Lang Julie, Leachman Sancy A, MacKie Rona M, Magnusson Veronica, Mann Graham J, Bishop Julia Newton, Palmer Jane M, Puig Susana, Puig-Butille Joan A, Stark Mitchell, Tsao Hensin, Tucker Margaret A, Whitaker Linda, Yakobson Emanuel
Abstract excerpt
BACKGROUND: The major factors individually reported to be associated with an increased frequency of CDKN2A mutations are increased number of patients with melanoma in a family, early age at melanoma diagnosis, and family members with multiple primary melanomas (MPM) or pancreatic cancer. METHODS:...
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