Patient-derived hepatitis C virus and JFH-1 clones differ in their ability to infect human hepatoma cells and lymphocytes.

doi:10.1099/vir.0.045393-0

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Article

Patient-derived hepatitis C virus and JFH-1 clones differ in their ability to infect human hepatoma cells and lymphocytes.

The Journal of general virology - 1 Nov 2012

Sarhan Mohammed A, Chen Annie Y, Russell Rodney S, Michalak Tomasz I

Abstract excerpt

Hepatitis C virus (HCV) is a hepatotropic virus that also infects cells of the immune system. HCV clones cultivated in human hepatoma Huh-7.5 cells have significantly advanced our understanding of HCV replication and candidate hepatocyte receptors. However, naturally occurring patient-derived HCV, in contrast to the HCV JFH-1 clone, is unable to infect Huh-7.5 cells, while it can replicate in human primary...

Topics

Adult
Carcinoma, Hepatocellular
Cell Line, Tumor
DNA, Complementary
Genotype
Hepacivirus
Hepatitis C, Chronic
Humans
Liver Neoplasms
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Viral

Reverse Transcriptase Polymerase Chain Reaction

Signal Transduction

T-Lymphocytes

Viral Tropism

Virus Replication

Source

Open in PubMed

Identifiers

PMID: 22855787
DOI: 10.1099/vir.0.045393-0

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