Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Patient-derived hepatitis C virus and JFH-1 clones differ in their ability to infect human hepatoma cells and lymphocytes.

The Journal of general virology - 1 Nov 2012

Sarhan Mohammed A, Chen Annie Y, Russell Rodney S, Michalak Tomasz I

Abstract excerpt

Hepatitis C virus (HCV) is a hepatotropic virus that also infects cells of the immune system. HCV clones cultivated in human hepatoma Huh-7.5 cells have significantly advanced our understanding of HCV replication and candidate hepatocyte receptors. However, naturally occurring patient-derived HCV, in contrast to the HCV JFH-1 clone, is unable to infect Huh-7.5 cells, while it can replicate in human primary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepacivirus

Share to Hepatitis C, Chronic

Share to Liver Neoplasms

Share to T-Lymphocytes

Share to Viral Tropism

Share to Virus Replication

Source

Identifiers

PMID: 22855787
DOI: 10.1099/vir.0.045393-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Patient-derived hepatitis C virus and JFH-1 clones differ in their ability to infect human hepatoma cells and lymphocytes.PMID 22855787Read ↗

Hepatitis C virus infection in phenotypically distinct Huh7 cell lines.Semantic proximity Read ↗

Permissivity of primary human hepatocytes and different hepatoma cell lines to cell culture adapted hepatitis C virus.Semantic proximity Read ↗

Isolation and Characterization of an Huh.7.5.1-Derived Cell Clone Highly Permissive to Hepatitis C VirusSemantic proximity Read ↗

Efficient infectious cell culture systems of the hepatitis C virus (HCV) prototype strains HCV-1 and H77.Semantic proximity Read ↗

Current status and future development of infectious cell-culture models for the major genotypes of hepatitis C virus: Essential tools in testing of antivirals and emerging vaccine strategies.Semantic proximity Read ↗

Genotype 1a HCV (H77S) infection system.Semantic proximity Read ↗

Production of infectious hepatitis C virus of various genotypes in cell cultures.Semantic proximity Read ↗

Direct infection and replication of naturally occurring hepatitis C virus genotypes 1, 2, 3 and 4 in normal human hepatocyte cultures.Semantic proximity Read ↗

A subclone of HuH-7 with enhanced intracellular hepatitis C virus production and evasion of virus related-cell cycle arrest.Semantic proximity Read ↗

Robust hepatitis C virus infection <i>in vitro</i>Semantic proximity Read ↗

Robust hepatitis C genotype 3a cell culture releasing adapted intergenotypic 3a/2a (S52/JFH1) viruses.Semantic proximity Read ↗

Production of infectious chimeric hepatitis C virus genotype 2b harboring minimal regions of JFH-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.