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Article

Does the Mutant CAG Expansion in Huntingtin mRNA Interfere with Exonucleolytic Cleavage of its First Exon?

Journal of Huntington's disease - 1 Jan 2016

Liu Wanzhao, Pfister Edith L, Kennington Lori A, Chase Kathryn O, Mueller Christian, DiFiglia Marian, Aronin Neil

Abstract excerpt

BACKGROUND: Silencing mutant huntingtin mRNA by RNA interference (RNAi) is a therapeutic strategy for Huntington's disease. RNAi induces specific endonucleolytic cleavage of the target HTT mRNA, followed by exonucleolytic processing of the cleaved mRNA fragments. OBJECTIVES: We investigated the clearance of huntingtin mRNA cleavage products following RNAi, to find if particular huntingtin mRNA sequences persist....

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Source

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Identifiers

PMID: 27003665
DOI: 10.3233/JHD-150183
PMCID: PMC4816656

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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