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Article

NAMPT Is the Cellular Target of STF-31-Like Small-Molecule Probes

24 Jul 2014

Abstract excerpt

The small-molecule probes STF-31 and its analogue compound 146 were discovered while searching for compounds that kill VHL-deficient renal cell carcinoma cell lines selectively and have been reported to act via direct inhibition of the glucose transporter GLUT1. We profiled the sensitivity of 679 cancer cell lines to STF-31 and found that the pattern of response is tightly correlated with sensitivity to three...

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PMID: 25058389
DOI: 10.1021/cb500347p

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