Article
A mesenchymal-like phenotype and expression of CD44 predict lack of apoptotic response to sorafenib in liver tumor cells.
International journal of cancer - 15 Feb 2015
Fernando Joan, Malfettone Andrea, Cepeda Edgar B, Vilarrasa-Blasi Roser, Bertran Esther, Raimondi Giulia, Fabra Àngels, Alvarez-Barrientos Alberto, Fernández-Salguero Pedro, Fernández-Rodríguez Conrado M, Giannelli Gianluigi, Sancho Patricia, Fabregat Isabel
Abstract excerpt
The multikinase inhibitor sorafenib is the only effective drug in advanced cases of hepatocellular carcinoma (HCC). However, response differs among patients and effectiveness only implies a delay. We have recently described that sorafenib sensitizes HCC cells to apoptosis. In this work, we have explored the response to this drug of six different liver tumor cell lines to define a phenotypic signature that may...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.