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Article

Cisplatin-induced activation of TGF-β signaling contributes to drug resistance

16 Nov 2023

Abstract excerpt

Growing evidence suggests an association between epithelial-mesenchymal transition (EMT), a hallmark of tumor malignancy, and chemoresistance to a number of anti-cancer drugs. However, the mechanism of EMT induction in the process of acquiring anti-cancer drug resistance remains unclear. To address this issue, we obtained a number of cisplatin-resistant clones from LoVo cells and found that almost all of them...

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PMID: 38188677
DOI: 10.32604/or.2023.030190

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