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Article

CD44s regulates the TGF-β-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma.

Cancer research - 1 Jul 2012

Mima Kosuke, Okabe Hirohisa, Ishimoto Takatsugu, Hayashi Hiromitsu, Nakagawa Shigeki, Kuroki Hideyuki, Watanabe Masayuki, Beppu Toru, Tamada Mayumi, Nagano Osamu, Saya Hideyuki, Baba Hideo

Abstract excerpt

The prognosis for individuals diagnosed with hepatocellular carcinoma (HCC) remains poor because of the high frequency of invasive tumor growth, intrahepatic spread, and extrahepatic metastasis. Here, we investigated the role of the standard isoform of CD44 (CD44s), a major adhesion molecule of the extracellular matrix and a cancer stem cell marker, in the TGF-β-mediated mesenchymal phenotype of HCC. We found...

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PMID: 22552294
DOI: 10.1158/0008-5472.CAN-12-0299

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