Article
Living the PCSK9 adventure: from the identification of a new gene in familial hypercholesterolemia towards a potential new class of anticholesterol drugs.
Current atherosclerosis reports - 1 Sept 2014
Abifadel Marianne, Elbitar Sandy, El Khoury Petra, Ghaleb Youmna, Chémaly Mélody, Moussalli Marie-Line, Rabès Jean-Pierre, Varret Mathilde, Boileau Catherine
Abstract excerpt
A decade after our discovery of the involvement of proprotein convertase subtilisin/kexin type 9 (PCSK9) in cholesterol metabolism through the identification of the first mutations leading to hypercholesterolemia, PCSK9 has become one of the most promising targets in cholesterol and cardiovascular diseases. This challenging work in the genetics of hypercholesterolemia paved the way for a plethora of studies...
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