Article
Rab17-mediated recycling endosomes contribute to autophagosome formation in response to Group AStreptococcusinvasion
23 Jul 2014
Abstract excerpt
Autophagy plays a crucial role in host defence by facilitating the degradation of invading bacteria such as Group A Streptococcus (GAS). GAS-containing autophagosome-like vacuoles (GcAVs) form when GAS-targeting autophagic membranes entrap invading bacteria. However, the membrane origin and the precise molecular mechanism that underlies GcAV formation remain unclear. In this study, we found that Rab17 mediates...
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