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Article

Group A Streptococcus modulates RAB1- and PIK3C3 complex-dependent autophagy

10 Jun 2019

Abstract excerpt

Autophagy selectively targets invading bacteria to defend cells, whereas bacterial pathogens counteract autophagy to survive in cells. The initiation of canonical autophagy involves the PIK3C3 complex, but autophagy targeting Group A Streptococcus (GAS) is PIK3C3-independent. We report that GAS infection elicits both PIK3C3-dependent and -independent autophagy, and that the GAS effector NAD-glycohydrolase (Nga)...

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PMID: 31177902
DOI: 10.1080/15548627.2019.1628539

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