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Article

An Initial Step of GAS-Containing Autophagosome-Like Vacuoles Formation Requires Rab7

26 Nov 2009

Abstract excerpt

Group A streptococcus (GAS; Streptococcus pyogenes) is a common pathogen that invades non-phagocytic human cells via endocytosis. Once taken up by cells, it escapes from the endocytic pathway to the cytoplasm, but here it is contained within a membrane-bound structure termed GAS-containing autophagosome-like vacuoles (GcAVs). The autophagosome marker GFP-LC3 associates with GcAVs, and other components of the...

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PMID: 19956673
DOI: 10.1371/journal.ppat.1000670

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