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Article

Diaporine, a novel endophyte-derived regulator of macrophage differentiation.

Organic & biomolecular chemistry - 14 Sept 2014

Wu Hao Chen, Ge Hui Ming, Zang Le Yun, Bei Yun Cheng, Niu Zhi Yuan, Wei Wei, Feng Xiu Jing, Ding Sen, Ng Seik Weng, Shen Ping Ping, Tan Ren Xiang

Abstract excerpt

Diaporine (1), an unprecedented symmetric polyketide, was characterized from the endophytic fungus. The structure was determined by extensive spectroscopic analyses. Diaporine can inhibit significantly the differentiation of macrophages and has potential to induce conversion from the M2 to the M1 phenotype, in addition to regulation of the TLR4-MAPK signal pathway and PPARγ activity.

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Source

Identifiers

PMID: 25051017
DOI: 10.1039/c4ob01123f

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TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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