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Anti-inflammatory and Neuroprotective α-Pyrones from a Marine-Derived Strain of the Fungus <i>Arthrinium arundinis</i> and Their Heterologous Expression

30 Apr 2024

Abstract excerpt

Fungal linear polyketides, such as α-pyrones with a 6-alkenyl chain, have been a rich source of biologically active compounds. Two new ( 1 and 2 ) and four known ( 3 – 6 ) 6-alkenylpyrone polyketides were isolated from a marine-derived strain of the fungus Arthrinium arundinis . Their structures were determined based on extensive spectroscopic analysis. The biosynthetic gene cluster ( alt ) for alternapyrones was...

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PMID: 38687877
DOI: 10.1021/acs.jnatprod.4c00393

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