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Genome mining and OSMAC strategies unveil diverse secondary metabolites from the endophytic fungus Diaporthe kyushuensis ZMU-48-1 with antifungal activity

10 Jun 2025

Abstract excerpt

Fungal-derived bioactive natural products are a crucial resource for drug discovery; however, under standard laboratory cultivation conditions, fungi predominantly yield known and repetitively isolated metabolites. This metabolic constraint presents a major obstacle to the discovery of structurally novel and bioactive secondary metabolites. Recent advances in whole-genome sequencing have revealed that a...

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PMID: 40556888
DOI: 10.3389/fmicb.2025.1604639

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