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A genetic pedigree analysis to identify gene mutations involved in femoral head necrosis

22 Jul 2014

Abstract excerpt

The present study presents results from a linkage and mutation screening analysis aiming to identify the causative gene of femoral head necrosis, also known as osteonecrosis of femoral head (ONFH), in a Chinese pedigree. We collected clinical data on the osteonecrosis pedigree, and extracted blood and genomic DNA from the family members. Polymerase chain reaction (PCR) and direct sequencing allowed to identify a...

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PMID: 25050885
DOI: 10.3892/mmr.2014.2410

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